Deletion in chromosome 11 and Bcl-1/Cyclin D1 alterations are independently associated with the development of uterine cervical carcinoma
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Deletion in chromosome 11 and Bcl-1/Cyclin D1 alterations
are independently associated with the development of
uterine cervical carcinoma
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| Creator |
Singh, Ratnesh Kumar
Dasgupta, Santanu Bhattacharya, Nilanjana Chunder, Neelanjana Mondal, Ranajit Kumar Roy, Anup Mandal, Syamsundar Roychoudhury, Susanta Panda, Chinmay Kumar |
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| Subject |
Molecular & Human Genetics
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| Description |
The aim of this study was to understand
whether there is any association between specific
deleted regions in chromosome 11 (chr.11) and alteration
(amplification/rearrangement) of Bcl-1/Cyclin D1
locus, located at 11q13, in uterine cervical carcinoma
(CA-CX). Methods: The deletion mapping of chr.11 was
studied using 17 highly polymorphic microsatellite
markers in 65 primary uterine cervical lesions. The Bcl-
1/Cyclin D1 alterations were analyzed by Southern blot
and/or polymerase chain reaction (PCR) method in
respective cervical lesions. Results: Chr.11 deletion was
found to be significantly associated with progression of
CA-CX. High frequency (48–65%) of deletion was
found in 11p15.5 (D1), 11q22.3–23.1(D2), and 11q23.3–
24.1(D3) regions and significant association was seen
among deletions in D2 and D3 regions. Bcl-1/Cyclin D1
locus alteration was observed in overall 27% cervical lesions. Co-amplification of Bcl-1/Cyclin D1 locus was
seen in 10% samples. However, no association was
found between the deleted regions and Bcl-1/Cyclin D1
locus alterations. Conclusions: Our study suggests that
there is no co-operativity between the deleted regions
(D1- D3) in chr.11 and Bcl-1/Cyclin D1 alterations, but
these alterations may provide cumulative effect in progression
of the tumor. The D1–D3 regions may harbor
candidate tumor suppressor gene(s) (TSGs) associated
with the development of CA-CX.
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| Publisher |
Springer Verlag
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/377/1/JOURNAL_OF_CANCER_RESEARCH_AND_CLINICAL_ONCOLOGY_131(_6)__395%2D406;2005[58].pdf
Singh, Ratnesh Kumar and Dasgupta, Santanu and Bhattacharya, Nilanjana and Chunder, Neelanjana and Mondal, Ranajit Kumar and Roy, Anup and Mandal, Syamsundar and Roychoudhury, Susanta and Panda, Chinmay Kumar (2005) Deletion in chromosome 11 and Bcl-1/Cyclin D1 alterations are independently associated with the development of uterine cervical carcinoma. Journal of Cancer Research and Clinical Oncology, 131 (6). pp. 395-406. |
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| Relation |
http://dx.doi.org/10.1007/s00432-004-0655-7
http://www.eprints.iicb.res.in/377/ |
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