Leishmania donovani Bisubunit Topoisomerase I Gene Fusion Leads to an Active Enzyme with Conserved Type IB Enzyme Function
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Leishmania donovani Bisubunit Topoisomerase I Gene
Fusion Leads to an Active Enzyme with Conserved Type IB
Enzyme Function
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| Creator |
Das, Benu Brata
Bose Dasgupta, Somdeb Ganguly, Agneyo Mazumder, Saumyabrata Roy, Amit Majumder, Hemanta K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
All eukaryotic topoisomerase I enzymes are monomeric enzymes, whereas the kinetoplastid family (Trypanosoma and Leishmania) possess an unusual bisubunit topoisomerase I. To determine what happens to the enzyme architecture and catalytic property if the two subunits are fused, and to
explore the functional relationship between the two subunits, we describe here in vitro gene fusion of Leishmania bisubunit topoisomerase I into a
single ORF encoding a new monomeric topoisomerase I (LdTOPIL-fus-S).
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/387/1/FEBS_JOURNAL%2C_274_(1)%2C__150%2D163_%2C2007_[133].pdf
Das, Benu Brata and Bose Dasgupta, Somdeb and Ganguly, Agneyo and Mazumder, Saumyabrata and Roy, Amit and Majumder, Hemanta K (2007) Leishmania donovani Bisubunit Topoisomerase I Gene Fusion Leads to an Active Enzyme with Conserved Type IB Enzyme Function. FEBS Journal , 274 (1). pp. 150-163. |
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| Relation |
http://dx.doi.org/10.1111/j.1742-4658.2006.05572.x
http://www.eprints.iicb.res.in/387/ |
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