Involvement of Pitx2, a Homeodomain Transcription Factor, in Hypothyroidism Associated Reproductive Disorders
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Involvement of Pitx2, a Homeodomain Transcription Factor, in Hypothyroidism Associated Reproductive Disorders
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| Creator |
Ghosh, Pamela
Saha, Samir Kumar Nandi, Shyam Sundar Bhattacharya, Samir Roy, Sib Sankar |
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| Subject |
Cell Biology & Physiology
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| Description |
Hypothyroid-associated reproductive disorders have
now become a striking phenomenon worldwide but
the molecular mechanism behind these disorders is
not fully known. Pitx2 gene encodes homeodomain
transcription factor, which regulates Plod2 gene in
brain tissue, transactivates gonadotropin genes in
pituitary and plays a substantial role in cell growth
and proliferation in different tissues. Pitx2 binds to
Plod2 promoter and activates this gene in rat ovary.
In this report, we show that Pitx2’s expression is
markedly reduced in hypothyroid ovary as well as in
ovarian granulosa cells, which is recovered with T3-
supplementation both in vitro and in vivo conditions.
Reduced Pitx2 expression could decrease Plod2
expression and hence facilitate ovarian ECM
degradation. We have also observed similar pattern
of expression of Pitx1 and -3 in hypothyroid and T3-
supplemented ovaries. The temporal expression of
Pitx2 across the estrous cycle shows that it is
expressed through all the 4 phases of the cycle and
reaches its maximum in the proestrus phase suggesting its possible role in ovulation followed by
luteinization. The present study reveals that the
reduced Pitx2 expression in hypothyroid ovary could
lead to ovarian dysfunction by modulating the Pitx2-
Plod2 interaction, further study will be necessary to
unravel the complete regulatory mechanism of Pitx2
in ovarian function.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/388/1/CELLULAR_PHYSIOLOGY_AND_BIOCHEMISTRY%2C__20(_6)%2C__887%2D898%2C2007_[137].pdf
Ghosh, Pamela and Saha, Samir Kumar and Nandi, Shyam Sundar and Bhattacharya, Samir and Roy, Sib Sankar (2007) Involvement of Pitx2, a Homeodomain Transcription Factor, in Hypothyroidism Associated Reproductive Disorders. Cell Physiol Biochem , 20 (6). pp. 887-898. |
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| Relation |
http://dx.doi.org/
http://www.eprints.iicb.res.in/388/ |
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