Prevention of Bone Loss by Oil Extract of Garlic (Allium sativum Linn.) in an Ovariectomized Rat Model of Osteoporosis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Prevention of Bone Loss by Oil Extract
of Garlic (Allium sativum Linn.) in an
Ovariectomized Rat Model of Osteoporosis
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| Creator |
Mukherjee, M
Das, A S Mitra, S Mitra, C |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The effects of oil extract of garlic (Allium sativum Linn.) on different primary and secondary osteoporotic
marker changes were tested in an ovariectomized rat model of osteoporosis. Experiments were performed on
three different rat models: sham-operated control, ovariectomized and ovariectomized supplemented with
garlic oil. In ovariectomized group, there has been a significant increase in different relative organ weights
compared to sham-operated control, while the uterine weight was found to be decreased. Supplementation
with oil extract of garlic could effectively reverse these changes. Also low bone densities that developed in the
ovariectomized group were significantly recovered in the garlic oil supplemented group. In our study, the
development of high rate of bone turnover and osteoporosis in the ovariectomized animals were confirmed by
significant alteration of serum alkaline phosphatase activity, serum tartrate resistant acid phosphatase activity,
urinary excretion of calcium, phosphate, hydroxyproline and urinary calcium to creatinine ratio, when compared
with the sham-operated control group. Garlic oil extract supplementation, apart from its unique influence in
lowering blood cholesterol, could also prevent ovariectomy-induced rise in all the above-mentioned marker
changes. The results of this study emphasize that oil extract of garlic possibly has a positive role in suppressing
ovariectomy-induced bone resorption. Copyright © 2004 John Wiley & Sons, Ltd.
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| Date |
2004
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/415/1/PHYTOTHERAPY_RESEARCH%2C_18_(_5)%2C_389%2D394_[59].pdf
Mukherjee, M and Das, A S and Mitra, S and Mitra, C (2004) Prevention of Bone Loss by Oil Extract of Garlic (Allium sativum Linn.) in an Ovariectomized Rat Model of Osteoporosis. PHYTOTHERAPY RESEARCH, 18 (5). pp. 389-394. |
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| Relation |
http://dx.doi.org/10.1002/ptr.1448
http://www.eprints.iicb.res.in/415/ |
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