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Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata


Field	Value

Title	Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

Creator	Murugesh, Kandasamy Yeligar, Veerendra Dash, Deepak Kumar Sengupta, Pinaki Maiti, Bhim Chandra Maity, Tapan Kumar

Subject	Chemistry

Description	The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.

Date	2006

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://www.eprints.iicb.res.in/420/1/BIOLOGICAL_%26_PHARMACEUTICAL_BULLETIN%2C_29_(_11)%2C__2202%2D2205%2C_[18].pdf Murugesh, Kandasamy and Yeligar, Veerendra and Dash, Deepak Kumar and Sengupta, Pinaki and Maiti, Bhim Chandra and Maity, Tapan Kumar (2006) Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats. Biol. Pharm. Bull, 29 (11). pp. 2202-2205.

Relation	htpp://dx.doi.org/10.1248/bpb.29.2202 http://www.eprints.iicb.res.in/420/