Aspirin Curtails the Acetaminophen-Induced Rise in Brain Norepinephrine Levels
IR@IICB: CSIR-Indian Institute of Chemical Biology, KolkataView Archive Info
Aspirin Curtails the Acetaminophen-Induced Rise
in Brain Norepinephrine Levels
Maharaj, Deepa S
Saravanan, Karuppagounder S
Mohanakumar , K P
Cell Biology & Physiology
We previously showed that acetaminophen administration to rats increases forebrain serotonin
levels as a result of the inhibition of liver tryptophan-2,3-dioxygenase (TDO). In this
study we determined whether aspirin alone and in combination with acetaminophen could
further influence brain serotonin as well as norepinephrine levels and if so whether the
status of the liver TDO activity would be altered. The results show that acetaminophen
alone increases brain serotonin as well as norepinephrine levels with a concomitant inhibition
of liver TDO activity. In contrast, aspirin did not alter the levels of these monoamines
but increased serotonin turnover in the brain while acetaminophen decreased the turnover.
When combined with acetaminophen, aspirin overrides the reduced serotonin turnover induced
by acetaminophen. This report demonstrates the potential of these agents to alter
neurotransmitter levels in the brain.
Maharaj, Himant and Maharaj, Deepa S and Saravanan, Karuppagounder S and Mohanakumar , K P and Daya, Santy (2004) Aspirin Curtails the Acetaminophen-Induced Rise in Brain Norepinephrine Levels. Metabolic Brain Disease, 19 (1-2). pp. 71-77.