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Melatonin protects against piroxicam-induced gastric ulceration

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Melatonin protects against piroxicam-induced gastric ulceration
Creator Bandyopadhyay, Debasish
Ghosh, Goutam
Bandyopadhyay, Arun
Reiter, Russel J
Subject Cell Biology & Physiology
Description The antiulcer e.ect of melatonin on gastric lesions caused by piroxicam was studied with the intent of determining the mechanism of action of this agent. Melatonin dose-dependently lowered piroxicam and indomethacin-induced gastric damage with more than 90% inhibition at a dose of 60 mg/kg BW. Increased lipid peroxidation, augmented protein oxidation and decreased glutathione content of the gastric tissue following piroxicam treatment indicated a possible involvement of oxidative stress in this nonsteroidal anti-in.ammatory drug (NSAID)-induced gastropathy. Pretreatment of rats with melatonin prevented these changes. Oral administration of piroxicam to rats caused a threefold increase in the tissue levels of hydroxyl radical generation, a change signi.cantly attenuated by melatonin. Furthermore, a decrease in the activity of gastric peroxidase and an increase in the activity of gastric superoxide dismutase(s) (SOD) because of piroxicam treatment was attenuated by melatonin pretreatment indicating that the indole possibly exerts its gastroprotective e.ects through its direct as well as indirect antioxidant activities. The results of the present studies also reveal that melatonin may in.uence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment. The current studies, therefore, document melatonin’s gastroprotective ability against piroxicam-induced gastric damage and the .ndings raise the possibility of melatonin being considered as a co-therapy with piroxicam or other NSAIDs in reducing the gastropathy when long-term use of these nonsteroidal agents are unavoidable.
Date 2004
Type Article
Format application/pdf
Identifier http://www.eprints.iicb.res.in/427/1/JOURNAL_OF_PINEAL_RESEARCH%2C_36(_3)%2C_195%2D203_[67].pdf
Bandyopadhyay, Debasish and Ghosh, Goutam and Bandyopadhyay, Arun and Reiter, Russel J (2004) Melatonin protects against piroxicam-induced gastric ulceration. J. Pineal Res, 36 (3). pp. 195-203.
Relation http://dx.doi.org/10.1111/j.1600-079X.2004.00118.x