Topoisomerases of kinetoplastid parasites: why so fascinating
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Topoisomerases of kinetoplastid parasites:
why so fascinating
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| Creator |
Das, Benu Brata
Sengupta, Tanushri Ganguly, Agneyo Majumder, Hemanta K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
DNA topoisomerases are the key enzymes involved in
carrying out high precision DNA transactions inside
the cells. However, they are detrimental to the cell
when a wide variety of topoisomerase-targeted drugs
generate cytotoxic lesions by trapping the enzymes in
covalent complexes on the DNA. The discovery of
unusual heterodimeric topoisomerase I in kinetoplastid
family added a new twist in topoisomerase
research related to evolution, functional conservation
and their preferential sensitivity to Camptothecin. On
the other hand, structural and mechanistic studies on
kinetoplastid topoisomerase II delineate some distinguishing
features that differentiate the parasitic
enzyme from its prokaryotic and eukaryotic
counterparts. This review summarizes the recent
advances in research in kinetoplastid topoisomerases,
their evolutionary significance and the
death of the unicellular parasite Leishmania donovani
induced by topoisomerase I inhibitor camptothecin
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/432/1/MOLECULAR_MICROBIOLOGY%2C__62_(_4)%2C__917%2D927%2C2006_[17].pdf
Das, Benu Brata and Sengupta, Tanushri and Ganguly, Agneyo and Majumder, Hemanta K (2006) Topoisomerases of kinetoplastid parasites: why so fascinating. Molecular Microbiology, 62 (4). pp. 917-927. |
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| Relation |
http://dx.doi.org/10.1111/j.1365-2958.2006.05428.x
http://www.eprints.iicb.res.in/432/ |
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