Role of Matrix Metalloproteinases in Ethanol-induced Gastric Ulcer and Diabetic Gastric Ulcer: Effects of Antioxidants
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Role of Matrix Metalloproteinases
in Ethanol-induced Gastric Ulcer and Diabetic
Gastric Ulcer: Effects of Antioxidants
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| Creator |
Singh, Laishram Pradeepkumar
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
At the beginning of 20th century the elucidation of molecular mechanism of
gastric ulcer was initiated. It has been known since 19th century that exposure of
the gastric mucosa to concentrated alcohol can induce acute gastritis (Beaumont,
1977). Approximately 29% of male and 9% of female patients in general hospitals
sign of alcohol-related diseases of the internal organs (Siegmund et al., 2005).
Thus, there is a high demand for alcohol research in gastroenterology to develop
more effective strategies to prevent and treat alcohol-related diseases. Both
macroscopically as well as microscopically ethanol produce marked damage to
the gastric tissues of animal models, resembling the pathogenicity occurring in
the human ulcer. NSAID-related gastric ulcers accounts for approximately 26% of
gastric ulcers. Mostly prescribed for the treatment of pain and inflammation in
many conditions, long-term consumption of NSAID however, is known to be
associated to gastric hyperacidity and ulceration.
Diabetes mellitus is a condition in which a person has a high blood sugar
(glucose) level either due to less production of insulin, or because body cells do
not properly respond to the insulin that is produced. It is associated to many
complications of which macrovascular disease, nephropathy, retinopathy and
neuropathy are the most common by which hyperglycaemia can disrupt cell and
organ function (Tripathi and Srivastava, 2006). Long standing diabetes leads to
gastrointestinal complications like gastroparesis, intestinal enteropathy (which
can cause diarrhea, constipation, and fecal incontinence), and nonalcoholic fatty
liver disease (Bytzer et al., 2001; Bytzer et al., 2002).
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| Date |
2010
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/458/1/LAISHRAM_PRADEEPKUMAR_SINGH_THESIS.pdf
Singh, Laishram Pradeepkumar (2010) Role of Matrix Metalloproteinases in Ethanol-induced Gastric Ulcer and Diabetic Gastric Ulcer: Effects of Antioxidants. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/458/
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