Role of Oil Extract of Garlic (Allium sativum Linn.) on Intestinal Transference of Calcium and Its Possible Correlation with Preservation of Skeletal Health in an Ovariectomized Rat Model of Osteoporosis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Role of Oil Extract of Garlic (Allium sativum Linn.) on Intestinal Transference of Calcium and Its Possible Correlation with Preservation of Skeletal Health in an Ovariectomized Rat Model of Osteoporosis
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| Creator |
Mukherjee, Maitrayee
Das, Asankur Sekhar Das, Dolan Mukherjee, Sandip Mitra, Smita Mitra, Chandan |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The present study was undertaken to examine the effects of an oil extract of garlic on the in vivo intestinal
transference of calcium, and also to verify its role in maintaining the bone mineral content and bone tensile
strength in an ovariectomized rat model of osteoporosis. The results suggest that, in this experimental model,
oil extract of garlic promotes intestinal transference of calcium by modulating the activities of both intestinal
alkaline phosphatase and Ca2+ activated ATPase. Also the observed low bone mineral content and low bone
tensile strength in these rats were significantly restored by garlic oil supplementation. Further, garlic oil
supplementation was able to revive partially the bilateral ovariectomy-induced decrease in the serum estrogen
titer. The serum parathyroid hormone level, however, was found unaltered in these rats. The garlic oil supplemented
partial recovery in serum estrogen titer in bilaterally ovariectomized rat was found to be persistently
associated with enhanced calcium transference and better preservation of bone mineral content. The results of
this study propose that the phytoestrogenic efficacy of an oil extract of garlic prevents ovarian hormone
deficiency induced bone mineral loss possibly by promoting intestinal transference of calcium through the
partial revival of the serum estrogen titer. Copyright © 2006 John Wiley & Sons, Ltd.
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/470/1/PHYTOTHERAPY_RESEARCH%2C__20(_5)%2C_408%2D415_[93].pdf
Mukherjee, Maitrayee and Das, Asankur Sekhar and Das, Dolan and Mukherjee, Sandip and Mitra, Smita and Mitra, Chandan (2006) Role of Oil Extract of Garlic (Allium sativum Linn.) on Intestinal Transference of Calcium and Its Possible Correlation with Preservation of Skeletal Health in an Ovariectomized Rat Model of Osteoporosis. Phytotherapy Research, 20 (5). pp. 408-415. |
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| Relation |
http://dx.doi.org/10.1002/ptr.1888
http://www.eprints.iicb.res.in/470/ |
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