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A Novel Approach for the One-Pot Synthesis of Linear and Angular Fused Quinazolinones

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title A Novel Approach for the One-Pot Synthesis of Linear and Angular Fused Quinazolinones
 
Creator Maity, Arindam
Mondal, Shyamal
Paira, Rupankar
Hazra, Abhijit
Naskar, Subhendu
Sahu, Krishnendu B
Saha, Pritam
Banerjee, Sukdeb
Mondal, Nirup B
 
Subject Chemistry
 
Description A convenient and inexpensive one step methodology has been developed for the synthesis of linear and angular fused quinazolinones. The protocol, which uses amino heterocycles and o-bromo benzyl/naphthyl bromides as reactants, CuI as catalyst, Cs2CO3 as base, L-proline as ligand, and DMF as solvent, proceeds via nucleophilic aromatic substitution of the N-heteroaromatic cationic intermediate followed by in situ aerial oxidation at the benzylic position to the quinazolinone scaffold.
 
Publisher Elsevier
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/473/1/arindam_tl.pdf
Maity, Arindam and Mondal, Shyamal and Paira, Rupankar and Hazra, Abhijit and Naskar, Subhendu and Sahu, Krishnendu B and Saha, Pritam and Banerjee, Sukdeb and Mondal, Nirup B (2011) A Novel Approach for the One-Pot Synthesis of Linear and Angular Fused Quinazolinones. Tetrahedron Letters, 52 (23). pp. 3033-3037. ISSN 00404039
 
Relation http://dx.doi.org/10.1016/j.tetlet.2011.04.019
http://www.eprints.iicb.res.in/473/