Competitive Growth Advantage of Nontoxigenic Mutants in the Stationary Phase in Archival Cultures of Pathogenic Vibrio cholerae Strains
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Competitive Growth Advantage of Nontoxigenic Mutants in the
Stationary Phase in Archival Cultures of Pathogenic
Vibrio cholerae Strains
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| Creator |
Paul, Kalidas
Ghosh, Amalendu Sengupta, Nilanjan Chowdhury, Rukhsana |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Spontaneous nontoxigenic mutants of highly pathogenic Vibrio cholerae O1 strains accumulate in large
numbers during long-term storage of the cultures in agar stabs. In these mutants, production of the transcriptional
regulator ToxR was reduced due to the presence of a mutation in the ribosome-binding site
immediately upstream of the toxR open reading frame. Consequently, the ToxR-dependent virulence regulon
was turned off, with concomitant reduction in the expression of cholera toxin and toxin-coregulated pilus. An
intriguing feature of these mutants is that they have a competitive fitness advantage when grown in competition
with the parent strains in stationary-phase cocultures which is independent of RpoS, the only locus known to
be primarily associated with acquisition of a growth advantage phenotype in bacteria.
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| Publisher |
American Society for Microbiology
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| Date |
2004
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/528/1/INFECTION_AND_IMMUNITY%2C__72(_9)%2C__5478%2D5482_[23].pdf
Paul, Kalidas and Ghosh, Amalendu and Sengupta, Nilanjan and Chowdhury, Rukhsana (2004) Competitive Growth Advantage of Nontoxigenic Mutants in the Stationary Phase in Archival Cultures of Pathogenic Vibrio cholerae Strains. Infection and Immunity, 72 (9). pp. 5478-5482. |
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| Relation |
http://dx.doi.org/10.1128/IAI.72.9.5478–5482.2004
http://www.eprints.iicb.res.in/528/ |
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