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Micronuclei as Biomarkers of Carcinogen Exposure in Populations Exposed to Arsenic through Drinking Water in West Bengal, India: A Comparative Study in Three Cell Types

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Micronuclei as Biomarkers of Carcinogen Exposure in Populations Exposed to Arsenic through Drinking Water in West Bengal, India: A Comparative Study in Three Cell Types
 
Creator Basu, Anamika
Ghosh, Pritha
Das, Jayanta K
Banerjee, Apurba
Ray, Kunal
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description Contamination of groundwater by arsenic, a paradoxical human carcinogen, has become a cause of global public health concern. In West Bengal, India, the groundwater in 9 of 18 districts is heavily contaminated with arsenic. Various adverse health effects including cancer have been reported from these districts and are associated with prolonged arsenic exposure. A cross-sectional biomarker study was conducted to evaluate and compare the frequencies of micronuclei in peripheral blood lymphocytes, oral mucosa cells, and urothelial cells from the inhabitants of North 24 Parganas, one of the arsenic-affected districts. The three cell types were collected from 163 residents exposed to high levels of arsenic in drinking water (214.7213 F 9.0273 Mg/l) and from 154 unexposed subjects residing in the unaffected East Midnapur district with very little or no exposure to arsenic through drinking water (9.2017 F 0.3157 Mg/l). Our analysis revealed that micronuclei frequencies in the exposed group were significantly elevated to 5.33-fold over unexposed levels for lymphocytes, 4.63-fold for oral mucosa cells, and 4.71-fold for urothelial cells (increases in micronuclei frequencies significant at P < 0.01). The results indicate that chronic ingestion of arsenic in drinking water by the exposed subjects is linked to the enhanced incidence of micronuclei in all the three cell types, slightly higher level of micronuclei being observed in lymphocytes compared with oral mucosa and urothelial cells.
 
Publisher Blackwell Publishing
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/532/1/CANCER_EPIDEMIOLOGY_BIOMARKERS_%26_PREVENTION%2C_13(_5)%2C_820%2D827_[60].pdf
Basu, Anamika and Ghosh, Pritha and Das, Jayanta K and Banerjee, Apurba and Ray, Kunal and Giri, Ashok K (2004) Micronuclei as Biomarkers of Carcinogen Exposure in Populations Exposed to Arsenic through Drinking Water in West Bengal, India: A Comparative Study in Three Cell Types. European Journal Of Biochemistry, 271 (4). pp. 753-759.
 
Relation http://dx.doi.org/:10.1111/j.1432-1033.2003.03974.x
http://www.eprints.iicb.res.in/532/