A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A randomized single-blind controlled trial of letrozole
as a low-cost IVF protocol in women with poor ovarian
response: a preliminary report
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| Creator |
Goswami, S.K
Das, T Chattopadhyay, R Sawhney, V Kumar, J Chaudhuri, K Chakravarty, B N Kabir, S N |
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| Subject |
Cell Biology & Physiology
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| Description |
Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to
induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF
protocol for poor responders. METHODS: A randomized, controlled, single-blind trial was conducted in the
Assisted Reproduction Unit, Institute of Reproductive Medicine, Kolkata, India. Thirty-eight women with a history
of poor ovarian response to gonadotrophins were recruited. Thirteen women (Let-FSH group) received letrozole
2.5mg daily from day 3–7, and recombinant FSH (rFSH) 75 IU/day on days 3 and 8; and 25 women (GnRHag-
FSH group) underwent long GnRH agonist protocol and stimulated with rFSH (300–450 IU/day). Ovulation
was triggered by 10 000 IU of HCG followed by IVF-embryo transfer. The main outcome measures were total dose
of rFSH (IU/cycle), terminal estradiol (E2) (pg/ml), numbers of follicles, oocytes retrieved and transferable embryo,
endometrial thickness (mm), and pregnancy rate. RESULTS: Compared with the GnRH-ag-FSH group
(2865 6 228 IU), the Let-FSH group (150 6 0 IU) received a significantly (P < 0.001) lower total dose of FSH.
Except for terminal E2, which was significantly higher (P < 0.001) in the GnRH-ag-FSH group (380 6 46 pg/ml)
than the Let-FSH group (227 6 45 pg/ml), the treatment outcomes in all other respects, including pregnancy rate,
were statistically comparable. CONCLUSIONS: Adjunctive use of letrozole may form an effective means of lowcost
IVF protocol in poorly responding women.
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| Publisher |
Oxford University Press
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| Date |
2004
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/535/1/HUMAN_REPRODUCTION%2C_19_(_9)%2C__2031%2D2035_[31].pdf
Goswami, S.K and Das, T and Chattopadhyay, R and Sawhney, V and Kumar, J and Chaudhuri, K and Chakravarty, B N and Kabir, S N (2004) A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Human Reproduction, 19 (9). pp. 2031-2035. |
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| Relation |
http://dx.doi.org/10.1093/humrep/deh359
http://www.eprints.iicb.res.in/535/ |
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