Dendritic Cell-Based Immunotherapy Combined with Antimony-Based Chemotherapy Cures Established Murine Visceral Leishmaniasis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Dendritic Cell-Based Immunotherapy Combined with
Antimony-Based Chemotherapy Cures Established Murine
Visceral Leishmaniasis
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| Creator |
Ghosh, Monidipa
Pal, Chiranjib Ray, Mitali Maitra, Sudipta Mandal, Labanya Bandyopadhyay, Santu |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Dendritic cells (DCs) have been proposed to play a critical role as adjuvants in vaccination and immunotherapy. In this study we
evaluated the combined effect of soluble Leishmania donovani Ag (SLDA)-pulsed syngeneic bone marrow-derived DC-based
immunotherapy and antimony-based chemotherapy for the treatment of established murine visceral leishmaniasis. Three weekly
injections of SLDA-pulsed DCs into L. donovani-infected mice reduced liver and splenic parasite burden significantly, but could
not clear parasite load from these organs completely. Strikingly, the conventional antileishmanial chemotherapy (sodium antimony
gluconate) along with injections of SLDA-pulsed DCs resulted in complete clearance of parasites from both these organs. Repetitive
in vitro stimulation of splenocytes from uninfected or L. donovani-infected mice with SLDA-pulsed DCs led to the emergence
of CD4� T cells with characteristics of Th1 cells. Our data indicate that DC-based immunotherapy enhances the in vivo antileishmanial
potential of antimony or vice versa.
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| Date |
2003
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/559/1/JOURNAL_OF_IMMUNOLOGY%2C_170(_11)%2C5625%2D5629[58].pdf
Ghosh, Monidipa and Pal, Chiranjib and Ray, Mitali and Maitra, Sudipta and Mandal, Labanya and Bandyopadhyay, Santu (2003) Dendritic Cell-Based Immunotherapy Combined with Antimony-Based Chemotherapy Cures Established Murine Visceral Leishmaniasis. The Journal of Immunology, 170 (11). pp. 5625-5629. |
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| Relation |
http://dx.doi.org/
http://www.eprints.iicb.res.in/559/ |
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