Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Increased interferon gamma production by peripheral blood
mononuclear cells in response to stimulation of overexpressed
disease-specific 9-O-acetylated sialoglycoconjugates in children
suffering from acute lymphoblastic leukaemia
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| Creator |
Ghosh, Shyamasree
Bandyopadhyay, Suman Pal, Santanu Das, Benubrata Bhattacharya, Dilip K Mandal, Chitra |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Disease-specific over-expression of 9-O-acetylated sialoglycoconjugates (9-OAcSGs)
on peripheral blood mononuclear cells (PBMC) of children with
acute lymphoblastic leukaemia (ALL, PBMCALL) has been demonstrated
using a lectin, Achatinin-H, with specificity towards 9-O-AcSAa2-6GalNAc.
This study investigated the contributory role of 9-O-AcSGs induced on
PBMCALL. Stimulation of PBMCALL with Achatinin-H through 9-O-AcSGs
led to a lymphoproliferative response with a significantly increased
interferon-c (IFN-c) production when compared with unstimulated cells as
demonstrated by enzyme-linked immunosorbent assay and mRNA
expression. Under identical conditions, PBMCALL ablated of O-acetylations
did not respond to such stimulation. In summary, it may be concluded that
stimulation of over-expressed 9-O-AcSGs regulate signalling for proliferation,
leading to the release of IFN-c. Controlled expression of these molecules may
be exploited as potential targets for therapy, promising beneficial effects to
children with ALL.
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| Publisher |
Blackwell Publishing
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| Date |
2005
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/568/1/BRITISH_JOURNAL_OF_HAEMATOLOGY__128(_1)_35%2D41;2005[117].pdf
Ghosh, Shyamasree and Bandyopadhyay, Suman and Pal, Santanu and Das, Benubrata and Bhattacharya, Dilip K and Mandal, Chitra (2005) Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia. British Journal Of Haematology, 128 (1). pp. 35-41. |
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| Relation |
http://dx.doi.org/10.1111/j.1365-2141.2004.05256.x
http://www.eprints.iicb.res.in/568/ |
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