Oxidative damage of erythrocytes: a possible mechanism for premature hemolysis in experimental visceral leishmaniasis in hamsters
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Oxidative damage of erythrocytes: a possible mechanism
for premature hemolysis in experimental visceral leishmaniasis
in hamsters
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| Creator |
Sen, G
Mukhopadhyay, R Ghosal, J Biswas, Tuli |
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| Subject |
Cell Biology & Physiology
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| Description |
Visceral leishmaniasis is accompanied by severe
anemia and pancytopenia. Reactive oxygen species
are known to contribute to the pathogenesis of several
red blood cell (RBCs) disorders. The present study
reveals the extent of oxidative stress and the efficacy of
the primary antioxidant system in erythrocytes of hamsters
in the progressive anemic response at different
stages of leishmanial infection. Increased intracellular
precipitation of Heinz bodies secondary to oxidative
denaturation of hemoglobin and enhanced formation
of malonyldialdehyde suggest oxidative damage of erythrocytes,
both in the hemoglobin and cell membrane,
respectively. Decreased activities of superoxide dismutase
and catalase in the infected animals indicate the
generation of O2
0 – and H2O2, which in turn may produce
the highly reactive 0OH species. Decreases in the
reduced glutathione level along with the decreased activities
of glutathione reductase and glutathione peroxidase
point to a deficient antioxidant defense system
during the post-infection period. Accentuated degradation
of both cytoskeletal and integral membrane proteins
after 3 months of infection may eventually lead to
membrane destabilization and early lysis of erythrocytes
in experimental visceral leishmaniasis.
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| Date |
2001
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/605/1/ANNALS_OF_HEMATOLOGY%2C_80(_1)%2C_32%2D37%2C2001[64].pdf
Sen, G and Mukhopadhyay, R and Ghosal, J and Biswas, Tuli (2001) Oxidative damage of erythrocytes: a possible mechanism for premature hemolysis in experimental visceral leishmaniasis in hamsters. Ann Hematol, 80 (1). pp. 32-37. |
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| Relation |
http://dx.doi.org/4735197/6793/0492,
http://www.eprints.iicb.res.in/605/ |
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