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Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine
 
Creator Chattopadhyay, Aindrila
Biswas, Sabyasachi
Bandyopadhyay, Debashis
Sarkar, Chinmoy
Datta, Asoke G
 
Subject Cell Biology & Physiology
 
Description Administration of isoproterenol to mice at a dose of 30 mg/100 g body weight for 3 consecutive days at an interval of 24 h induced lipid peroxidation in cardiac tissue and exhibited a significantly elevated serum glutamate oxaloacetate transaminase (SGOT) level. Increased superoxide dismutase (SOD) activity with a concomitant decrease in catalase activity has also been observed in cardiac tissue with isoproterenol treatment. Quinidine, a class I antiarrhythmic agent has been found to exhibit a protective role in isoproterenol induced myocardial ischaemia. Cardiac tissue of quinidine treated mice showed reduction of lipid peroxidation reaction. In addition, quinidine treatment is found to influence the cardiac antioxidant enzymes – catalase and SOD. The decrease of SOD activity and increase of catalase activity suggests that quinidine also exerts an ‘indirect antioxidant’ effect in protecting the myocardial tissue from reactive oxygen species. Furthermore, our current in vitro studies with quinidine have clearly shown in this work that it possesses a very convincing hydroxyl radical scavenging potential with almost no ability to scavenge superoxide anion and hydrogen peroxide (H2O2) in vitro. Thus, our present investigation suggests that quinidine, when administered to mice, strengthens the antioxidant defense system to resist the free radical induced damage brought about by isoproterenol induced ischaemic condition. (Mol Cell Biochem 245: 43–49, 2003)
 
Publisher Kluwer
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/612/1/MOLECULAR_AND_CELLULAR_BIOCHEMISTRY%2C_245(_1%2D2)%2C_43%2D49_[78].pdf
Chattopadhyay, Aindrila and Biswas, Sabyasachi and Bandyopadhyay, Debashis and Sarkar, Chinmoy and Datta, Asoke G (2003) Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine. Molecular and Cellular Biochemistry, 245 (1-2). pp. 43-49.
 
Relation http://dx.doi.org/10.1023/A:1022808224917
http://www.eprints.iicb.res.in/612/