Immunobiology of Granulocyte Macrophage Colony Stimulating Factor Driven Human Myeloid Cells
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Immunobiology of Granulocyte Macrophage Colony Stimulating Factor Driven Human Myeloid Cells
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| Creator |
Ganguly, Dipyaman
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| Subject |
Infectious Diseases and Immunology
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| Description |
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is well known to have growth-promoting activities on hematopoietic cell lineages. GM-CSF is known to stimulate multipotent progenitors depending on its concentration. Both in human and mouse, it was cloned from cDNA library of activated T lymphocytes. Various subsets of T lymphocytes have been found to produce GM-CSF on activation, although its direct effect on the T lymphocytes is not yet very clear. Most of the demonstrated effects of GM-CSF are believed to be
mediated by the antigen presenting cells. Therapeutic uses of GMCSF, like G-CSF (Granulocyte Colony Stimulatory Factor), mainly involve treating neutropenia of different etiologies. Specifically, for treating chemotherapy-induced neutropenia and for expansion of
hematopoietic progenitors prior to autologous transplantation, GMCSF and G-CSF have been in extensive use. Although they surely have growth-promoting activity on multi-lineage hematopoietic cells, possibilities are there that they also might have some immunomodulatory activities brought about by differential effects on
different immune cells.
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| Date |
2006
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/614/1/Dipyaman_Ganguly%2C_PhD_thesis%2C_2006.pdf
Ganguly, Dipyaman (2006) Immunobiology of Granulocyte Macrophage Colony Stimulating Factor Driven Human Myeloid Cells. PhD thesis, West Bengal University of Technology. |
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| Relation |
http://www.eprints.iicb.res.in/614/
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