Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Infection of Human Mononuclear Phagocytes and
Macrophage-Like THP1 Cells with Leishmania
donovani Results in Modulation of Expression of a
Subset of Chemokines and a Chemokine Receptor
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| Creator |
Dasgupta, B
Roychoudhury, K Ganguly, S Akbar, M A Das, P Roy, Syamal |
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| Subject |
Infectious Diseases and Immunology
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| Description |
The expression of chemokines and chemokine receptors was studied in
Leishmania donovani (LD)-infected human mononuclear phagocytes and the
human monocytic cell line THP1. Our studies showed that LD infection caused
the upregulation of three b chemokines (macrophage inflammatory protein-1
alpha (MIP-1a), MIP-1b and RANTES (regulated on activation normal T cell
expressed and secreted)), one a chemokine (interleukin-8 (IL-8)) and the CC
chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase-
polymerase chain reaction (RT-PCR) analysis. The CCR5 upregulation
in human mononuclear phagocytes and THP1 cells was also evident by
confocal microscopy. The possible association of such upregulation in relation to
Leishmania and human immunodeficiency virus (HIV) coinfection was discussed
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| Publisher |
Blackwell Publishing
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| Date |
2003
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/616/1/SCANDINAVIAN_JOURNAL_OF_IMMUNOLOGY%2C_57(_4)%2C366%2D374[70].pdf
Dasgupta, B and Roychoudhury, K and Ganguly, S and Akbar, M A and Das, P and Roy, Syamal (2003) Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor. Scandinavian Journal Of Immunology, 57 (4). pp. 366-374. |
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| Relation |
http://dx.doi.org/10.1046/j.1365-3083.2003.01227.x
http://www.eprints.iicb.res.in/616/ |
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