Synthesis of Enantiomerically Pure Nucleosides and Analogues Involving Carbohydrates as Chiral Pool
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Synthesis of Enantiomerically Pure Nucleosides and Analogues Involving Carbohydrates as Chiral Pool
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| Creator |
Roy, Biswajit Gopal
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| Subject |
Chemistry
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| Description |
The area of carbocyclic nucleosides has developed after the isolation of (-)-aristeromycin (1) and
(-)-neplanocin A (2) from natural sources showing antileukemic activity. Many of the carbocyclic
nucleosides, arising from the replacement of the furanose ring oxygen by a carbon atom, exhibit
interesting antiviral properties against herpes simplex virus (HSV 1 and 2), human cytomegalovirus,
hepatitis B virus and human immunodeficiency virus (HIV). One of the reasons for the remarkable
activities of this class of nucleosides is their better chemical as well as metabolic stability against
various chemicals and enzymes. Among various analogues, carbovir (3), and abacavir (4),
carboxetanocin G (5), (-)-BCA (6), BVDU (7) and carba-2/-ara-fluoroguanosine (8) show important
biological properties. Carbocyclic nucleosides containing cyclohexenyl, cyclohexyl (9 and 10), and
cyclopropyl (11 and 12) analogues have also been reported to be potential inhibitors of HIV, cancer
and viruses
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| Date |
2007
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/625/1/Thesis%2D_BIswajit_Gopal_Roy.pdf
Roy, Biswajit Gopal (2007) Synthesis of Enantiomerically Pure Nucleosides and Analogues Involving Carbohydrates as Chiral Pool. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/625/
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