Effect of Pelvic Endometrial Implants on Overall Reproductive Functions of Female Rats
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Effect of Pelvic Endometrial Implants on Overall Reproductive Functions
of Female Rats
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| Creator |
Pal, Alok K
Biswas, Shampa Goswami, S K Kabir, S N |
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| Subject |
Cell Biology & Physiology
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| Description |
The effects of pelvic endometrial implants on the overall reproductive
potential of female rats were investigated. After homologous
transplantation in the peritoneum, the ectopic endometrium
developed into highly vascularized nodes that gradually
increased in mass until the 9th week postsurgery and then
plateaued. In the presence of these implants, overall reproductive
function was adversely affected. The effect was of greatest
magnitude during 50–70 days posttransplantation. As compared
with values in corresponding controls, ovulation was reduced
by 43% (6 of 14) (p , 0.05), mating rate was reduced by 44%
(12 of 27) (p , 0.025), and premature termination of pregnancy
occurred in 34% (5 of 15) of rats. Wastage of pregnancy, which
included complete termination or reduction of fetal number, occurred
during the postimplantation course of gestation. Furthermore,
100% of the rats with transplants failed to respond
to the copulomimetic stimulation for the induction of pseudopregnancy
(p , 0.01, compared with corresponding controls).
However, on exposure to vasectomized males, 46% (6 of 13) of
these rats exhibited development of pseudopregnancy (p ,
0.05, compared with corresponding group receiving copulomimetic
stimulation). Increased rate of mating failure and differential
pseudopregnancy rates after copulomimetic and natural
cervical stimulation suggest that the rats with endometrial explants
possibly had an absence or a short appearance of behavioral
estrus. Hormonal assessment during the preovulatory
phase showed a tendency toward lower mean levels of preovulatory
estradiol and significantly lower LH (p , 0.01) and progesterone
(p , 0.01) concentrations. The adversely affected reproductive
functions may be a secondary consequence of these
altered endocrine milieus.
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| Date |
1999
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/663/1/BIOLOGY_OF_REPRODUCTION__60(_4)954%2D958;1999[62].pdf
Pal, Alok K and Biswas, Shampa and Goswami, S K and Kabir, S N (1999) Effect of Pelvic Endometrial Implants on Overall Reproductive Functions of Female Rats. Biology of Reproduction, 60 (4). pp. 954-958. |
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| Relation |
http://dx.doi.org/10.1095/biolreprod60.4.954
http://www.eprints.iicb.res.in/663/ |
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