Anticarcinogenic Activity of Nanoencapsulated Quercetin in Combating Diethylnitrosamine-induced Hepatocarcinoma in Rats
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Anticarcinogenic Activity of Nanoencapsulated Quercetin in
Combating Diethylnitrosamine-induced Hepatocarcinoma in Rats
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| Creator |
Ghosh, Aparajita
Ghosh, Debasree Sarkar, Sibani Mandal, Ardhendu K Choudhury, Somsubhra Thakur Das, Nirmalendu |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Hepatocellular carcinoma is the most common primary
hepatic malignancy worldwide. N-Nitroso compounds act
as strong carcinogens in various animals, including
primates. Diethylnitrosamine (DEN) is a well known
carcinogenic substance, which induces hepatic carcinoma.
The theme of the study was to evaluate the therapeutic
efficacy of nanoencapsulated flavonoidal quercetin
(3,5,7,30,40-pentahydroxy flavone, QC) in combating
DEN-induced hepatocarcinogenesis in rats. DEN induced
a substantial increase in relative liver weights with
proliferation and development of hyperplastic nodules.
A significant increase in hepatocellular and nephrotoxicity
indicated by serum alkaline phosphatase, aspartate
transaminase, alanine transaminase, urea, and creatinine
was observed in DEN-treated animals. Maximum
protection from such toxicity was provided by
nanoparticulated QC. Elevated levels of conjugated
diene in DEN-treated rats were lowered significantly by
nanoparticulated QC. Antioxidant levels in hepatic
cells were reduced significantly by the induction
of DEN. Nanoparticulated QC was found most potent
for complete prevention of DEN-induced reduction
in antioxidant levels in the liver. Upregulation of
glutathione-S-transferase activity by DEN induction
was reduced maximally by nanoencapsulated QC.
Nanoencapsulated QC completely protected the
mitochondrial membrane of the liver from carcinoma
mediated by DEN injection. A significant correlation could
be drawn between DEN-induced tissue reactive oxygen
species generation and cytochrome C expression in the
liver. Nanoencapsulated QC completely prevented the
DEN-induced cytochrome C expression in the liver
significantly.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/689/1/Ghosh%2C_Aparajita_%2D_IICB.pdf
Ghosh, Aparajita and Ghosh, Debasree and Sarkar, Sibani and Mandal, Ardhendu K and Choudhury, Somsubhra Thakur and Das, Nirmalendu (2011) Anticarcinogenic Activity of Nanoencapsulated Quercetin in Combating Diethylnitrosamine-induced Hepatocarcinoma in Rats. European Journal of Cancer. |
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| Relation |
http://dx.doi.org/10.1097/CEJ.0b013e32834a7e2b
http://www.eprints.iicb.res.in/689/ |
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