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Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes
 
Creator Banerjee, Goutam
Nandi, Gopa
Mahato, Shashi B
Pakrashi, Anita
Basu, Mukul K
 
Subject Chemistry
 
Description Different sugar-grafted liposomes were prepared and tested against experimental leishmaniasis in vivo using the classical drug pentamidine isethionate and its methoxy derivative. Both the drugs, when encapsulated in sugar-grafted liposomes were found to be more potent in comparison to normal liposome-encapsulated drug or to the free drug. Moreover, the mannose-grafted liposomes were adjudged to be the best in lowering of spleen parasite load in comparison with those bearing glucose or galactose. When encapsulated in mannose-grafted liposomes the therapeutic efficacy of pentamidine isethionate was found to be better than that of its methoxy derivative, although the latter seemed to be less toxic than the pentamidine isethionate itself.
 
Date 1996
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/711/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY%2C_38_(_1)%2C_145%2D150_[32].pdf
Banerjee, Goutam and Nandi, Gopa and Mahato, Shashi B and Pakrashi, Anita and Basu, Mukul K (1996) Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes. Journal of Antimicrobial Chemotherapy, 38 (1). pp. 145-150.
 
Relation http://dx.doi.org/10.1093/jac/38.1.145
http://www.eprints.iicb.res.in/711/