Tubulin and Glial Fibrillary Acidic Protein Gene Expression in Developing Fetal Human Brain at Midgestation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Tubulin and Glial Fibrillary Acidic Protein Gene
Expression in Developing Fetal Human Brain
at Midgestation
|
|
| Creator |
Pal, Utpal
Chaudhury, Sukanya Sarkar, Pranab K |
|
| Subject |
Cell Biology & Physiology
|
|
| Description |
Developmental alterations in the expression of glial fibrillary acidic protein (GFAP) and A-tubulin
were examined at the level of mRNA and protein in human fetal brain between weeks 13-23
of gestation. Except for a transient increase at week 15, GFAP expression in the cytoskeletal
(CSK) fraction was low until week 17, when it increased steadily to week 23, corresponding to
the phase of glial proliferation. The developmental profile of A-tubulin in the CSK fraction displayed
a biphasic pattern, with an initial rise between weeks 13-16 coinciding with the early
phase of neuroblast multiplication, and a second rise between weeks 17-23 corresponding to the
phase of glial proliferation. No significant difference in the spatial distribution of A-tubulin was
found in different region of brain but GFAP expression varied with a higher level in cerebellum
than that in cerebrum at late midgestation.
|
|
| Publisher |
Kluwer
|
|
| Date |
1999
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/721/1/NEUROCHEMICAL_RESEARCH_24_(5)_637%2D641;1999[57].pdf
Pal, Utpal and Chaudhury, Sukanya and Sarkar, Pranab K (1999) Tubulin and Glial Fibrillary Acidic Protein Gene Expression in Developing Fetal Human Brain at Midgestation. Neurochemical Research, 24 (5). pp. 637-641. |
|
| Relation |
http://dx.doi.org/10.1023/A:1021096224161
http://www.eprints.iicb.res.in/721/ |
|