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Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms
 
Creator Medda, Swapna
Mukhopadhyay, Sibabrata
Basu, Mukul K
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description The antileishmanial property of amarogentin, a secoiridoid glycoside isolated from the Indian medicinal plant Swertia chirata, was examined in a hamster model of experimental leishmaniasis. The therapeutic efficacy of amarogentin was evaluated in free and two different vesicular forms, liposomes and niosomes. The amarogentin in both liposomal and niosomal forms was found to be a more active leishmanicidal agent than the free amarogentin; and the niosomal form was found to be more efficacious than the liposomal form at the same membrane microviscosity level. Toxicity studies involving blood pathology, histological staining of tissues and specific enzyme levels related to normal liver function showed no toxicity. Hence, amarogentin incorporated in liposomes or niosomes may have clinical application in the treatment of leishmaniasis
 
Publisher Oxford University Press
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/732/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY___44(_6)791%2D794;1999[4].pdf
Medda, Swapna and Mukhopadhyay, Sibabrata and Basu, Mukul K (1999) Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms. Journal of Antimicrobial Chemotherapy, 44 (6). pp. 791-794.
 
Relation http://dx.doi.org/10.1093/jac/44.6.791
http://www.eprints.iicb.res.in/732/