Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Combination Therapy with Indolylquinoline Derivative and
Sodium Antimony Gluconate Cures Established Visceral
Leishmaniasis in Hamsters
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| Creator |
Pal, Chiranjib
Raha, Mousumi Basu, Anirban Roy, Keshab Chandra Gupta, Anasuya Ghosh, Monidipa Sahu, N P Banerjee, Sukdeb Mondal, Nirup B Bandyopadhyay, Santu |
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| Subject |
Chemistry
Infectious Diseases and Immunology |
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| Description |
2-(2�-Dichloroacetamidobenzyl)-3-(3�-indolylquinoline), designated indolylquinoline derivative A, reduced
the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas
sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia
from the livers and spleens was noticed when infected animals received indolylquinoline derivative A
plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive
therapy for leishmaniasis.
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| Publisher |
American Society for Microbiology
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/744/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY_46(_1)_259%2D2612002[75].pdf
Pal, Chiranjib and Raha, Mousumi and Basu, Anirban and Roy, Keshab Chandra and Gupta, Anasuya and Ghosh, Monidipa and Sahu, N P and Banerjee, Sukdeb and Mondal, Nirup B and Bandyopadhyay, Santu (2002) Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters. Antimicrobial Agents and Chemotherapy, 46 (1). pp. 259-261. |
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| Relation |
http://dx.doi.org/10.1128/AAC.46.1.259-261.2002
http://www.eprints.iicb.res.in/744/ |
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