Synthesis of a Novel Quinoline Derivative, 2-(2-Methylquinolin-4- ylamino)-N-phenylacetamide—A Potential Antileishmanial Agent
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Synthesis of a Novel Quinoline Derivative, 2-(2-Methylquinolin-4-
ylamino)-N-phenylacetamide—A Potential Antileishmanial Agent
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| Creator |
Sahu, Niranjan P
Pal, Chiranjib Mondal, Nirup B Banerjee, Sukdeb Raha, Mausumi Kundu, Ashis P Basu, Anirban Ghosh, Monidipa Roy, Keshab Bandyopadhyay, Santu |
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| Subject |
Chemistry
Infectious Diseases and Immunology |
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| Description |
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-
N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate
(SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results
suggest that the compound could be exploited as an antileishmanial drug. # 2002 Elsevier Science Ltd. All rights reserved.
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| Publisher |
Elsevier
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/748/1/BIOORGANIC_%26_MEDICINAL_CHEMISTRY_10_(_6)_1687%2D1693;2002[54].pdf
Sahu, Niranjan P and Pal, Chiranjib and Mondal, Nirup B and Banerjee, Sukdeb and Raha, Mausumi and Kundu, Ashis P and Basu, Anirban and Ghosh, Monidipa and Roy, Keshab and Bandyopadhyay, Santu (2002) Synthesis of a Novel Quinoline Derivative, 2-(2-Methylquinolin-4- ylamino)-N-phenylacetamide—A Potential Antileishmanial Agent. Bioorganic & Medicinal Chemistry, 10 (6). pp. 1687-1693. |
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| Relation |
http://dx.doi.org/10.1016/S0968-0896(02)00046-9
http://www.eprints.iicb.res.in/748/ |
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