Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Melatonin protects against gastric ulceration and increases the
efficacy of ranitidine and omeprazole in reducing gastric damage
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| Creator |
Bandyopadhyay, Debashis
Bandyopadhyay, Arun Das, Pratap K Reite, Russel J |
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| Subject |
Cell Biology & Physiology
Drug Development/Diagnostics & Biotechnology |
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| Description |
The antiulcer effect of melatonin on gastric lesions caused by
restraint-cold stress was studied with the intent of determining the
mechanism of action of this agent. Melatonin dose-dependently prevented
restraint-cold stress-induced gastric damage with around 90% inhibition at a
dose of 60 mg/kg BW. When compared with already marketed antiulcer
drugs such as ranitidine and omeprazole, melatonin was found to be more
effective than ranitidine but less effective than omeprazole in preventing
stress ulcer. As stress-induced gastric lesions are mainly caused by oxidative
damage because of hydroxyl radicals (ÆOH), the effect of melatonin in
scavenging the ÆOH generated during stress conditions in vivo as well as in an
in vitro model system were studied. The results indicate that melatonin
caused an 88% reduction of endogenous ÆOH during stress in vivo, an
observation confirmed in an established in vitro system. Furthermore, a
decrease in the activity of gastric peroxidase (GPO) and an increase in the
gastric mitochondrial superoxide dismutase (Mn-SOD) activity because of
restraint-cold stress was attenuated by melatonin pretreatment indicating
that the indole possibly exerts its gastroprotective effects through its direct as
well as indirect antioxidant activities. Moreover, in separate experiments,
cotreatment of rats with melatonin and ranitidine or omeprazole was found
to protect against stress ulceration in doses at which either of these alone
could not protect the stomach. The findings raise the possibility of melatonin
being considered as an effective gastroprotective agent individually or as a
cotreatment with either ranitidine and omeprazole.
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| Publisher |
Blackwell Publishing
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/771/1/JOURNAL_OF_PINEAL_RESEARCH__33_(_1)_1%2D7;2002[34].pdf
Bandyopadhyay, Debashis and Bandyopadhyay, Arun and Das, Pratap K and Reite, Russel J (2002) Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. Journal Of Pineal Research, 33 (1). 01-07. |
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| Relation |
http://dx.doi.org/10.1034/j.1600-079X.2002.01107.x
http://www.eprints.iicb.res.in/771/ |
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