Antileishmanial Activities of Stearylamine-Bearing Liposomes
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Antileishmanial Activities of Stearylamine-Bearing Liposomes
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| Creator |
Dey, Tuhina
Anam, Khairul Afrin, Farhat Ali, Nahid |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA)
against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo
were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly
reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral
leishmaniasis, respectively, suggesting their strong therapeutic potential.
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| Publisher |
American Society for Microbiology
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| Date |
2000
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/800/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY__44(6)1739%2D1742;2000[37].pdf
Dey, Tuhina and Anam, Khairul and Afrin, Farhat and Ali, Nahid (2000) Antileishmanial Activities of Stearylamine-Bearing Liposomes. Antimicrobial Agents and Chemotherapy, 44 (6). pp. 1739-1742. |
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| Relation |
http://dx.doi.org/10.1128/AAC.44.6.1739-1742.2000
http://www.eprints.iicb.res.in/800/ |
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