The Effect of Anti-Prolactin Antibody on in Vitro Synthesis of a Pregnancy-Associated Rat Uterine Glycoprotein
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
The Effect of Anti-Prolactin Antibody on in Vitro
Synthesis of a Pregnancy-Associated Rat Uterine
Glycoprotein
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| Creator |
Mehta, Monika
Chowdhury, Mridula |
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| Subject |
Chemistry
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| Description |
Experiments were conducted to study the hormonal (estrogen [E2], progesterone [P4] and prolactin [PRL]), regulation of synthesis
of a pregnancy-associated glycoprotein (named Uterine Agglutinin or UA) in the Day 4 post coital (p.c.) rat uterus with antibody
administration and immunohistochemistry. Of the antibodies used, it was shown that anti-PRL antibody was the most effective
in reducing in vitro UA synthesis. The results suggested that in vitro UA synthesis could be correlated to serum PRL levels as
analyzed by radio-immunoassay. Binding studies revealed that PRL bound specifically to the stromal cells of the rat uterus
where UA is produced and localized.
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| Date |
1997
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/806/1/MOLECULAR_AND_CELLULAR_BIOCHEMISTRY%2C_177(_1%2D2)%2C_131%2D138[7].pdf
Mehta, Monika and Chowdhury, Mridula (1997) The Effect of Anti-Prolactin Antibody on in Vitro Synthesis of a Pregnancy-Associated Rat Uterine Glycoprotein. Molecular and Cellular Biochemistry, 177 (1-2). pp. 131-138. |
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| Relation |
http://dx.doi.org/10.1023/A:1006897011859
http://www.eprints.iicb.res.in/806/ |
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