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Comparative Mutagenic and Genotoxic Effects of Three Antimalarial Drugs, Chloroquine, Primaquine and Amodiaquine

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata

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Title Comparative Mutagenic and Genotoxic Effects of Three Antimalarial Drugs, Chloroquine, Primaquine and Amodiaquine
 
Creator Chatterjee, Taraknath
Muhkopadhyay, Amitabha
Khan, Kalim A
Giri, Ashok K
 
Subject Cell Biology & Physiology
 
Description Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine, were assessed in the Ames mutagenicity assay (in strains TA97a, TA100, TA102 and TA104) and in vivo sister chromatid exchange (SCE) and chromosome aberration (CA) assays in bone marrow cells of mice. These are the most commonly used antimalarial drugs available at present throughout the world. The results of the bacterial mutagenicity assays showed a very weak mutagenic effect of all three drugs in Salmonella strains TA97a and TA100 both with and without S9 mix and in TA104 only with S9 mix. The results of the in vivo SCE and CA assays indicate that these three drugs are genotoxic in bone marrow cells of mice.
 
Date 1998
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/827/1/MUTAGENESIS%2C_13(_6)%2C_619%2D624[13].pdf
Chatterjee, Taraknath and Muhkopadhyay, Amitabha and Khan, Kalim A and Giri, Ashok K (1998) Comparative Mutagenic and Genotoxic Effects of Three Antimalarial Drugs, Chloroquine, Primaquine and Amodiaquine. Mutagenesis, 13 (6). pp. 619-624.
 
Relation http://dx.doi.org/10.1093/mutage/13.6.619
http://www.eprints.iicb.res.in/827/