Altered Membrane Permeability as the Basis of Bactericidal Action of Methdilazine
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Altered Membrane Permeability as the Basis of Bactericidal Action of Methdilazine
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| Creator |
Chattopadhyaya, Debprasad
Mukherjee, Tanmoy Pal, Prajnamoy Saha, Bhaskar Bhadra, Ranjan |
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| Subject |
Chemistry
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| Description |
The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by
significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14 glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without
visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.
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| Date |
1998
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/847/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY%2C__42(_1)%2C_83%2D86[31].pdf
Chattopadhyaya, Debprasad and Mukherjee, Tanmoy and Pal, Prajnamoy and Saha, Bhaskar and Bhadra, Ranjan (1998) Altered Membrane Permeability as the Basis of Bactericidal Action of Methdilazine. Journal of Antimicrobial Chemotherapy, 42 (1). pp. 83-86. |
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| Relation |
http://dx.doi.org/10.1093/jac/42.1.83
http://www.eprints.iicb.res.in/847/ |
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