A Novel Peptide-Grafted Liposomal Delivery System Targeted to Macrophages
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A Novel Peptide-Grafted Liposomal Delivery System
Targeted to Macrophages
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| Creator |
Banerjee, Goutam
Medda, Swapna Basu, Mukul K |
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| Subject |
Chemistry
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| Description |
The interaction of chemotactic peptide (e.g., fMet-Leu-Phe)-grafted liposomes with macrophages is noted to
be rapid and specific. At a grafted peptide concentration of 100 nmol, internalization of the peptide-grafted
liposomes by the macrophages is found to reach equilibrium in 30 min. The peptide alone and the peptidegrafted
empty liposomes are found to show moderate antileishmanial activity in vitro. Primaquine, which is
known to generate O2
2 in phagocytic cells, showed leishmanicidal properties when it was tested in vitro against
parasite-infected macrophages over a certain range of concentrations. It showed much better efficacy against
experimental leishmaniasis when it was used in the fMet-Leu-Phe-grafted liposomal form in comparison with
its efficacy when it was either in the free form or encapsulated in ungrafted liposomes. The conventional toxicity parameters (e.g., blood pathology and tissue histology-specific enzyme levels related to normal liver function) are found to be very close to normal when fMet-Leu-Phe-grafted liposomal primaquine is used. The biodegradabilities of both the drug and the delivery systems are also found to be very satisfactory. Thus, this delivery system may have possible applications for the treatment of leishmaniasis as well as other macrophageassociated disorders.
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| Date |
1998
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/857/1/ANTIMICROBIAL_AGENTS_AND_CHEMOTHERAPY%2C_42(_2)%2C_348%2D351[55].pdf
Banerjee, Goutam and Medda, Swapna and Basu, Mukul K (1998) A Novel Peptide-Grafted Liposomal Delivery System Targeted to Macrophages. Antimicrobial Agents and Chemotherapy, 42 (2). pp. 348-351. |
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| Relation |
http://dx.doi.org/
http://www.eprints.iicb.res.in/857/ |
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