Melatonin Protects Against Stress-Induced Gastric Lesions by Scavenging the Hydroxyl Radical
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Melatonin Protects Against Stress-Induced
Gastric Lesions by Scavenging the Hydroxyl
Radical
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| Creator |
Bandyopadhyay, D
Biswas, Kausik Bandyopadhyay, Uday Reiter , R J Banerjee, R K |
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| Subject |
Cell Biology & Physiology
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| Description |
The antiulcer effect of melatonin on gastric lesions caused by
restraint-cold stress or by indomethacin (IMN) was studied with the
intent of determining the mechanism of action of the indole. Melatonin
dose-dependently prevents both stress and IMN-induced gastric damage
with around 90% inhibition at a dose of 60 mg per kg BW. When
compared with already-marketed antiulcer drugs, such as ranitidine and
omeprazole, melatonin was found to be more effective than ranitidine
but less effective than omeprazole in preventing stress ulcer. When
compared with other antioxidants, melatonin was more potent than
glutathione and essentially equipotent to a-tocopherol in blocking
stress-induced ulcer. As stress-induced gastric lesions are mainly caused
by oxidative damage due to hydroxyl radicals (�OH), the effect of
melatonin in scavenging the �OH generated during stress conditions, as
well as in an in vitro model system, was studied. The results indicate
that melatonin at the dose of 60 mg per kg BW caused an 88%
reduction of endogenous �OH during stress. Melatonin was also highly
effective in scavenging �OH generated in vitro by a Cu2�-ascorbate
system. In this case, melatonin at 100 mM reduced �OH by 80%.
Melatonin was also found to be a more potent radical scavenger than
benzoate, a known �OH scavenger. The results indicate that melatonin
prevents stress-induced gastric lesions by scavenging the endogenous
�OH. As it also protects against IMN-induced gastric damage, it
probably also offers gastroprotection by maintaining endogenous
prostaglandin levels.
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| Publisher |
Blackwell Publishing
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| Date |
2000
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/862/1/JOURNAL_OF_PINEAL_RESEARCH__29(_3_)143%2D151;2000[14].pdf
Bandyopadhyay, D and Biswas, Kausik and Bandyopadhyay, Uday and Reiter , R J and Banerjee, R K (2000) Melatonin Protects Against Stress-Induced Gastric Lesions by Scavenging the Hydroxyl Radical. Journal Of Pineal Research, 29. pp. 143-151. |
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| Relation |
http://dx.doi.org/ 10.1034/j.1600-079X.2000.290303.x
http://www.eprints.iicb.res.in/862/ |
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