Prokinetic Effect of Black Tea on Gastrointestinal Motility
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Prokinetic Effect of Black Tea on Gastrointestinal Motility
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| Creator |
Chaudhuri, L
Basu, S Seth, P Chaudhuri, T Besra, S E Vedasiromoni, J R Ganguly, D K |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The gastrokinetic e%&ts of hot water extract of black tea [Camellia sinensis, (L)
0. Kuntze (Theaceae)] on gastrointestinal motility were studied both in vivo and
in vitro. The extract signiiicantly accelerated the gastrointestinal transit (GIT) in
vivo in mice. These f&litatory effect was reduced a&r pretreatment with
atropine, hemicholinium-3, morphine, indomethacin, McN-A-343 and L-arginine.
In guinea pig ileum, the extract facilitated the peristaltic reflex in response to
pressures in normal preparation. The black tea extract and L-NMMA (nitric oxide
synthase inhibitor) significantly reduced the electrical field stimulated
nonadrenergic, noncholinergic (NANC) relaxation of isolated rat fimdal strips.
The extract markedly enhanced the tonic (‘hump’) responses to transmural
stimulation iu longitudinal muscle of guinea pig ileum which was unaltered in the
presence of atropine. These findings suggest a cholinergic involvement and a
partial role of prostaglandin and nitric oxide in the mechanism of action of black
tea extract on gastrointestinal motility. To determine the effective constituents in
black tea responsible for this activity, the effect of black tea polyphenols on GIT
were also studied. Thearubigin fraction (but not theaflavin) accelerated GIT
significantly which suggests its involvement in the prokinetic effect of black tea.
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| Date |
2000
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/870/1/LIFE_SCIENCES__66_(9)_847%2D854;2000[65].pdf
Chaudhuri, L and Basu, S and Seth, P and Chaudhuri, T and Besra, S E and Vedasiromoni, J R and Ganguly, D K (2000) Prokinetic Effect of Black Tea on Gastrointestinal Motility. Life Sciences, 66 (9). pp. 847-854. |
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| Relation |
http://dx.doi.org/10.1016/S0024-3205(99)00657-8
http://www.eprints.iicb.res.in/870/ |
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