Protective Effect of Leaf Extract of Ficus hispida Linn. Against Paracetamol-induced Hepatotoxicity in Rats
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Protective Effect of Leaf Extract of Ficus
hispida Linn. Against Paracetamol-induced
Hepatotoxicity in Rats
|
|
| Creator |
Mandal, Subhash C
Saraswathi, B Kumar, C K Ashok Lakshmi, S Mohana Maiti, Bhim Chandra |
|
| Subject |
Chemistry
|
|
| Description |
The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective
activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral
dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase
(SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented
by histopathological examination of liver sections. The activity of extract was also comparable
to that of Liv-52 a known hepatoprotective formulation
|
|
| Date |
2000
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/883/1/PHYTOTHERAPY_RESEARCH__14(_6)457%2D459;2000[22].pdf
Mandal, Subhash C and Saraswathi, B and Kumar, C K Ashok and Lakshmi, S Mohana and Maiti, Bhim Chandra (2000) Protective Effect of Leaf Extract of Ficus hispida Linn. Against Paracetamol-induced Hepatotoxicity in Rats. Phytotherapy Research, 14 (6). pp. 457-459. |
|
| Relation |
http://dx.doi.org/10.1002/1099-1573(200009)14:6<457::AID-PTR610>3.0.CO;2-8
http://www.eprints.iicb.res.in/883/ |
|