Exploring The Role of Sialic Acids in Leishmaniasis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Exploring The Role of Sialic Acids in Leishmaniasis
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| Creator |
Ghosal, Angana
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| Subject |
Infectious Diseases and Immunology
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| Description |
The parasite has a digenetic life cycle (Figure 1.1) with an extracellular developmental stage in the insect vector, a female sandfly, and a developmental stage in mammals, which is mostly intracellular (Hespanhol et al. 2005). The transmission of leishmaniasis occurs through either from the Phlebotomus genus in the old world or from the Lutzomyia in the new world (Weniger et al. 2001). In sandflies, development of the parasite occurs in the alimentary canal with the formation of a motile, flagellated and elongated form termed a ‘promastigote’. The
promastigote matures in the insect midgut into an infective metacyclic promastigote (Ritting et al. 2000). Inoculation into the mammalian host occurs when Phlebotomus sandflies feed on blood, which is a requirement for oviposition. A typical inoculum contains around 100–1000 metacyclic promastigotes, which quickly become engulfed by leucocytes, particularly
macrophages, neutrophils and dendritic cells (Roberts MTM, 2006). The parasites undergo a further transformation within these cells to form amastigotes. A morphological change occurs as the parasite takes on an ovoid shape with a short flagellum, hence the term ‘amastigote’, and possibly a metabolic change with a switch to anaerobic metabolism under acidic conditions found chiefly in the phagolysosome compartment (Chang KP, 1990).
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| Date |
2009
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/902/1/Final_thesis_7th_january2009.pdf
Ghosal, Angana (2009) Exploring The Role of Sialic Acids in Leishmaniasis. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/902/
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