Microsatellite Instability in Squamous Cell Carcinoma of Head and Neck from the Indian Patient Population
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Microsatellite Instability in Squamous Cell Carcinoma of Head and Neck from the Indian Patient Population
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| Creator |
Chakraborty, Susmita
Dasgupta, Santanu Roy, Sangita Bhar, Anusree Sengupta, Arunava Roy , Anup Roy, Kunal Bhattacharyya, Nitai P Roy, Bidyut Panda, Chinmay Kumar Roychoudhury, Susanta |
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| Subject |
Molecular & Human Genetics
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| Description |
Genomic instability in simple repeated sequences has been
observed in several human cancers. We have analyzed 50
squamous cell carcinomas of the head and neck (SCCHN)
and 5 pre-malignant severe dysplastic tissues from Indian
patient populations for microsatellite instability in 18 different
loci spread over eight different chromosomes. Among
the tumors analyzed, 45% exhibited instability at two or
more loci, and 15%exhibited instability at 40%of the markers
tested. Similar analysis of SCCHN tumors fromother populations
(British, American and French) showed much less
frequency of instability. SCCHNtumors in the present study
did not show any instability in the mononucleotide repeat
sequences. There is also a clear distinction in the nature of the instability in these tumors in comparison with colorectal tumors. These results suggest that the underlying mechanismgenerating
this type of instability is different fromthose
reported for colorectal tumors.
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| Date |
2001
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/907/1/INTERNATIONAL_JOURNAL_OF_CANCER%2C_92_(4)%2C__555%2D561%2C_2001[38].pdf
Chakraborty, Susmita and Dasgupta, Santanu and Roy, Sangita and Bhar, Anusree and Sengupta, Arunava and Roy , Anup and Roy, Kunal and Bhattacharyya, Nitai P and Roy, Bidyut and Panda, Chinmay Kumar and Roychoudhury, Susanta (2001) Microsatellite Instability in Squamous Cell Carcinoma of Head and Neck from the Indian Patient Population. International Journal of Cancer, 94 (4). pp. 555-561. |
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| Relation |
http://dx.doi.org/10.1002/ijc.1233
http://www.eprints.iicb.res.in/907/ |
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