An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols
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| Creator |
Gupta, Pankaj
Taneja, Subhash C. Shah, Bhahwal A. Mukherjee, Debaraj Parshad, Rajinder Chimni, Swapandeep S. Qazi, Ghulam N. |
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| Subject |
Chemical Sciences
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| Description |
The expedient synthesis of enantiopure masked 1,2-amino alcohols (ee >99%) including their alkyl substituted
analogues has been achieved by the regioselective ring opening of epoxides using phthalimide,followed by highly efficient kinetic resolution under mild and environmentally friendly conditions. The addition of co-solvents during kinetic resolution significantly improved the enantioselectivity with reduction in time.
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| Date |
2008
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/206/1/10.1016j.tetasy.2008.08.004.pdf
Gupta, Pankaj and Taneja, Subhash C. and Shah, Bhahwal A. and Mukherjee, Debaraj and Parshad, Rajinder and Chimni, Swapandeep S. and Qazi, Ghulam N. (2008) An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols. Tetrahedron: Asymmetry, 19 (16). pp. 1898-1903. ISSN 09574166 |
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| Relation |
http://dx.doi.org/10.1016/j.tetasy.2008.08.004
http://iiim.csircentral.net/206/ |
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