A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus
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| Creator |
Sharma, Punita
Chauhan, Prashant S. Dutt, Prabhu Amina, Musarat Suri, Krishan A. Gupta, Bishan D. Suri, Om P. Dhar, Kanaya L. Sharma, Deepak Gupta, Vivek Satti, Naresh K. |
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| Subject |
Chemical Sciences
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| Description |
A new steroidal sapogenin molecule 1 having unique characteristics, 21-nor and unusual C19 carboxylic
acid has been isolated from the roots of Asparagus racemosus. On the basis of chemical evidence, extensive
spectroscopic analysis including two dimensional (2D) NMR and X-ray studies of single crystal,the structure of 1 was determined as(1S,2R,3S,8S,9S,10S,13S,14S,16S,17R,22R,25R)-21-nor-18�,27�-
dimethyl-1�,2�,3�-trihydroxy-25-spirost-4-en-19�-oic acid. 1 crystallizes in monoclinic space group P21 with a = 9.295(2), b = 11.238(2), c = 11.376(2)A˚ ; ˇ = 91.993(4)◦, Z = 2, Dcal = 1.344Mg/m3. The structure was solved by direct methods and refined by full-matrix least-squares procedure to a final R-value of 0.0561 for 4064 observed reflections. 1 was tested against the type of immune responses generated during treatment in normal and immune-suppressed animals and detailed biological activity evaluation suggests it to be a potent immunostimulator.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/199/1/10.1016j.steroids.2010.12.006.pdf
Sharma, Punita and Chauhan, Prashant S. and Dutt, Prabhu and Amina, Musarat and Suri, Krishan A. and Gupta, Bishan D. and Suri, Om P. and Dhar, Kanaya L. and Sharma, Deepak and Gupta, Vivek and Satti, Naresh K. (2011) A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus. Steroids, 76 (4). pp. 358-364. ISSN 0039128X |
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| Relation |
http://dx.doi.org/10.1016/j.steroids.2010.12.006
http://iiim.csircentral.net/199/ |
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