New cassane butenolide hemiketal diterpenes from the marine creeper Caesalpinia honduc and their antiproliferative activity
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Yadav, P P
Arora, Ashish Bid, H K Konwar, Rituraj Kanojiya, Sanjeev |
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| Date |
2007-11-14T09:43:17Z
2007-11-14T09:43:17Z 2007 |
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| Identifier |
Tetrahedron Letters 48 (2007) 7194-7198
http://hdl.handle.net/123456789/19 |
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| Description |
Two new cassane butenolides, caesalpinolide A (1) and B (2), epimeric at the hemiketal position were isolated from the
marine creeper Caesalpinia bonduc. The structures were elucidated by the analysis of spectroscopic data and relative stereochemistry was assigned on
the basis of ROESY correlations. Compounds 1 and 2 were found to inhibit MCF-7 breast cancer cell lines with ICso values of (IlM)12.8 and 6.1, respectively, along with the inhibition of endometrial and cervical cancer cell lines
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| Format |
582825 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication Number 7219
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| Title |
New cassane butenolide hemiketal diterpenes from the marine creeper Caesalpinia honduc and their
antiproliferative activity
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| Type |
Article
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