Regioselective Synthesis of 2-Amino-isophthalonitriles through a Ring Transformation Strategy
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Singh, Fateh V
Kumar, Vijay Kumar, Brijesh Goel, Atul |
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| Date |
2007-11-29T07:07:31Z
2007-11-29T07:07:31Z 2007 |
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| Identifier |
Tetrahedron(2007), 63, 10971-78
http://hdl.handle.net/123456789/32 |
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| Description |
An expeditious synthesis of several 2-amino-isophthalonitriles and their biaryl compounds is described and illustrated by carbanion-induced ring transformation of functionalized 2H-pyran-2-ones with malononitrile in excellent yields. The strength of the reaction lies in the creation of an aromatic ring at room temperature from six membered-lactones under mild reaction conditions. This approach is an alternative to Diels-Alder reactions of 2H-pyran-2-ones with dienophiles, which require forcing thermal conditions to obtain benzene derivatives.
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| Format |
512324 bytes
application/pdf |
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| Language |
en
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| Relation |
C.D.R.I. Communication No 7253
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| Subject |
Isophthalonitrile
benzene biaryl lactone 2H-pyran-2-one malononitrile |
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| Title |
Regioselective Synthesis of 2-Amino-isophthalonitriles through a Ring Transformation Strategy
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| Type |
Article
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