Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sashidhara, K V
Rosaiaha, J N Kumar, Abdhesh Bid, H K Konwar, Rituraj Chattopadhyay, Naibedya |
|
| Date |
2009-09-07T09:27:48Z
2009-09-07T09:27:48Z 2007 |
|
| Identifier |
Phytother Res.( 2007),21(11),1105-8
http://hdl.handle.net/123456789/502 |
|
| Description |
In the course of our studies on the isolation of bioactive compounds from the roots of Coleus forskohlii, a traditional herb in India, rare 13-epi-sclareol has been isolated, and its structure determined by extensive 2D NMR. And also this is the first report of isolation from this plant. Isolated compound showed anti-proliferative activity in breast and uterine cancers in vitro. The anti-proliferative activity of 13-epi-sclareol is comparable with Tamoxifen in terms of IC50 and also showed concentration dependent increased apoptotic changes in breast cancer cell line, MCF-7.
|
|
| Format |
89806 bytes
application/pdf |
|
| Language |
en
|
|
| Relation |
CDRI Communicatin No. 7122
|
|
| Subject |
13-epi-sclareol
Diterpene Anti-cancer Coleus forskohlii Apoptosis |
|
| Title |
Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro
|
|
| Type |
Article
|
|