Comparison of the Effect of Compound CDRI 80/53 [N-(3-acetyl-4,5-dihydro-2-furanyl)-N4-(6 -methoxy-8-quinolinyl)1,4- pentanediamine] with Primaquine on Human Erythrocytes In Vitro
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Anklesaria, P S
Ashar, V J Kshirsagar, N A Gupta, K C |
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| Date |
2009-09-08T08:58:57Z
2009-09-08T08:58:57Z 1994 |
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| Identifier |
Tropical diseases: molecular biology & control strategies,1994,256-261
http://hdl.handle.net/123456789/505 |
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| Description |
Comparative in vitro study of a malaria antirelapse compound CDRI Code
80/53 with primaquine (PQ) was done on the erythrocytes of eight normal and six G-6-PD-deficient individuals. Reduced glutathione (GSH) was estimated in the RBCs exposed to the in vitro action of the drugs. Statistically significant decreases were observed at 25 ug/ml and 50 ยต/ml doses of PQ as compared t the equivalent doses of compound 80/53 in both normal and G-6-PD-deficient erythrocytes. The study showed that compound CDRI 80/53 did not damage normal as well as G-6-PD-deficient erythrocytes to the same extent as PQ.
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| Format |
1382605 bytes
application/pdf |
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| Language |
en
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| Title |
Comparison of the Effect of Compound CDRI 80/53 [N-(3-acetyl-4,5-dihydro-2-furanyl)-N4-(6 -methoxy-8-quinolinyl)1,4- pentanediamine] with Primaquine on Human Erythrocytes In Vitro
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| Type |
Book chapter
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