Search for new pharmacophores for antimalarial activity (Part II): Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Madapa, Sudharshan
Tusi, Zehra Mishra, A Srivastava, K Pandey, S K Tripathi, R Puri, S K Batra, Sanjay |
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| Date |
2010-03-02T06:08:42Z
2010-03-02T06:08:42Z 2009 |
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| Identifier |
Bioorganic & Medicinal Chemistry 17 (2009) 222–234
http://hdl.handle.net/123456789/519 |
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| Description |
Synthesis of new 6-ureido-4-anilinoquinazolines have been accomplished and their in vitro antimalarial activity against chloroquine-sensitive P. falciparum have been examined. Out of 64 compounds evaluated, the IC50 of 16 compounds which have displayed MIC of 0.25 g/mL were also recorded. One of the compounds (24g) had IC50 value of 2.27 ng/mL which was equipotent to the standard drug chloroquine used in the bioassay. The in vivo evaluation of a few compounds among the series led to discovey of one analog (30g) displaying 40% curative activity (28 days) against mdr P. yoeilli nigeriensis at an oral dose of 100mg/kg x 4days
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| Format |
240861 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication Number 7626
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| Title |
Search for new pharmacophores for antimalarial activity (Part II): Synthesis and antimalarial activity of new 6-ureido-4-anilinoquinazolines
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| Type |
Article
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