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Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines

IR@CDRI: CSIR-Central Drug Research Institute, Lucknow

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Field Value
 
Creator Mishra, A
Srivastava, K
Tripathi, R
Puri, S K
Batra, Sanjay
 
Date 2010-03-02T06:27:37Z
2010-03-02T06:27:37Z
2009
 
Identifier European Journal of Medicinal Chemistry (2009), 44 (11), 4404-4412
http://hdl.handle.net/123456789/520
 
Description Syntheses and in vitro antimalarial evaluation of 42 new thioureido quinazolines have been carried out. Several analogs showed promising antimalarial effect in the in vitro investigation against chloroquine-sensitive 3D7 strain of P. falciparum whereas one of the compounds shows 50% curative effect in the mouse model at an oral dose of 100mg/kg x 4 days against multi drug resistant P. yoelii nigeriensis
 
Format 144420 bytes
application/pdf
 
Language en
 
Relation CDRI Communication Number 7714
 
Subject antimalarial
thioureido quinazolines
chloroquine
P. falciparum
P. yoelii nigeriensis
 
Title Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines
 
Type Article