Synthesis of 2-amino-3,4-dihydroquinazolines and imidazo[2,1-b]quinazoline-2-ones
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Mishra, Amita
Batra, Sanjay |
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| Date |
2010-03-02T09:08:29Z
2010-03-02T09:08:29Z 2009 |
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| Identifier |
Synthesis 2009, no. 18, 3077-88
http://hdl.handle.net/123456789/521 |
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| Description |
A facile method for the synthesis of 2-amino-3,4-dihydroquinazolines from the Baylis-Hillman derivatives has been disclosed. The protocol involves the sequential SN2-reaction of a primary amine on the Baylis-Hillman acetate of 2-nitrobenzaldehyde, CNBr-mediated nitrile addition and Fe-AcOH-promoted reductive cyclization. The approach has been extended for constructing imidazo[2,1-b]quinazoline-2-ones and imi-dazo[2,1-b]qinazolines in one pot.
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| Format |
274105 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication Number 7780
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| Subject |
Quinazoline
Anagrelide Baylis-Hillman imidazo[2,1-b]quinazoline allyl amine |
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| Title |
Synthesis of 2-amino-3,4-dihydroquinazolines and imidazo[2,1-b]quinazoline-2-ones
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| Type |
Article
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