9-O-Acetylated GD3 Triggers Programmed Cell Death in Mature Erythrocytes
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
9-O-Acetylated GD3 Triggers Programmed Cell Death in Mature Erythrocytes
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| Creator |
Mukherjee, Kankana
Chowdhury, Suchandra Mondal, Susmita Mandal, Chandan Chandra, Sarmila Bhadra, Rupak K Mandal, Chitra |
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| Subject |
Infectious Diseases and Immunology
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| Description |
An acetylated modification of a tumor-associated ganglioside GD3 (9-O-AcGD3) is expressed in certain tumors and present during
early stages of development in different tissues. However, the status and the role of 9-O-AcGD3 in the erythroid progenitor cells remain
unexplored. Here, we report the level of 9-O-AcGD3 during erythropoiesis in bone marrow is down regulated during maturation. Signaling
via 9-O-AcGD3 induces alteration of morphology and membrane characteristics of mature erythrocytes. This process also
induces, a cell death program in these erythrocytes even in the absence of nucleus, mitochondria and other cell organelles sharing features
of apoptosis in nucleated cells like membrane alterations, vesicularization, phosphatidyl serine exposure, activation of cysteine proteases
like caspase-3. This is the first report of a programmed cell death pathway in mature erythrocytes, triggered by 9-O-AcGD3 contrary to
their anti-apoptotic role in lymphoblasts, which suggests a cell specific role of this O-acetyl ester of GD3.
� 2007 Elsevier Inc. All rights reserved.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/1053/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__362_(3)_651%2D657;2007[25].pdf
Mukherjee, Kankana and Chowdhury, Suchandra and Mondal, Susmita and Mandal, Chandan and Chandra, Sarmila and Bhadra, Rupak K and Mandal, Chitra (2007) 9-O-Acetylated GD3 Triggers Programmed Cell Death in Mature Erythrocytes. Biochemical and Biophysical Research Communications, 362 (3). pp. 651-657. |
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| Relation |
http://dx.doi.org/10.1016/j.bbrc.2007.08.048
http://www.eprints.iicb.res.in/1053/ |
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