Host-virus interaction: a new role for microRNAs
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
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Title |
Host-virus interaction: a new role for microRNAs
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Creator |
Scaria, Vinod
Hariharan, Manoj Maiti, Souvik Pillai, Beena Brahmachari, Samir K. |
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Subject |
G1 Genome informatics (General)
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Description |
MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play critical
roles in a wide spectrum of biological processes. Recent reports also throw light into the role of
microRNAs as critical effectors in the intricate host-pathogen interaction networks. Evidence
suggests that both virus and hosts encode microRNAs. The exclusive dependence of viruses on the
host cellular machinery for their propagation and survival also make them highly susceptible to the
vagaries of the cellular environment like small RNA mediated interference. It also gives the virus an
opportunity to fight and/or modulate the host to suite its needs. Thus the range of interactions
possible through miRNA-mRNA cross-talk at the host-pathogen interface is large. These
interactions can be further fine-tuned in the host by changes in gene expression, mutations and
polymorphisms. In the pathogen, the high rate of mutations adds to the complexity of the
interaction network. Though evidence regarding microRNA mediated cross-talk in viral infections
is just emerging, it offers an immense opportunity not only to understand the intricacies of host-
pathogen interactions, and possible explanations to viral tropism, latency and oncogenesis, but also
to develop novel biomarkers and therapeutics.
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Date |
2006-10-11
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://openaccess.igib.res.in/89/1/1742%2D4690%2D3%2D68.pdf
Scaria, Vinod and Hariharan, Manoj and Maiti, Souvik and Pillai, Beena and Brahmachari, Samir K. (2006) Host-virus interaction: a new role for microRNAs. Retrovirology, 3. |
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Relation |
http://openaccess.igib.res.in/89/
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